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KMID : 0358519970090030508
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Korean Journal of Occupational and Environmental Medicine
1997 Volume.9 No. 3 p.508 ~ p.516
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The Expression of Interleukin-6 in Chronic CCI4-induced Hepatotoxicity in Ethanol-fed Rabbits
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김성숙/Kim SS
우영주/하은희/손희정/최인표/Woo YJ/Ha EH/Sohn HJ/Choi IP
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Abstract
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The pathogenesis of liver damage in alcoholic liver disease is not well understood, although there is evidence implicating immune mechanism. Among many aspects of the immune mechanism, the involvement such as interleukin-6 was suggest in alcoholic liver disease.
The authors studied in order to investigate whether IL-6 play a role in the pathogenesis of alcoholic liver disease. Rabbits were fed with ethanol mixed diet with subcutaneous injection of 1mg/kg of CCl4 (ethanol CCl4 group) or with same injection of normal saline (ethanol group) during the last 6 weeks of the whole 12 weeks periods of ethanol diet. The other groups were given ethanol free control diet with subcutaneous injection of CCl4 (CCl4 only group) or normal saline (control group) by the same method as the former two group.
The result were as follows:
1) The serum level of AST and ALT, ethanol only group an CCl4 only group tended to be elevated than control group. Especially those of ethanol- CCl4 group was significantly higher than any other three groups.
2) The serum level of IL-6 activity in ethanol only group and CCl4 only group tended to be elevated than control group. Especially that of ethanol-CCl4 group was significantly higher than any other three groups.
3) Commbining all four groups, there was significant correlation between the serum IL-6 and AST or ALT levels.
It can be concluded that IL-6 may reflect hepatic injury and play a role in liver disease, especially by CCl4.
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